Knight Cancer Institute - OHSU
Publications
The CNSB produces highly cited research findings that are widely disseminated via our dedicated web portals and public databases.
Our team has published over 300 peer-reviewed papers, including 75 in the past 5 years alone, which have garnered over 40,000 citations to date. These include first-in-class proteome-scale interaction maps for model organisms and human cancer cells.
DESP demixes cell-state profiles from dynamic bulk molecular measurements
Understanding the dynamic expression of proteins and other key molecules driving phenotypic remodeling in development and pathobiology has garnered widespread interest, yet the exploration of these systems at the foundational resolution of the underlying cell states has been significantly limited by technical constraints.
Dynamic Remodeling of Escherichia coli Interactome in Response to Environmental Perturbations
Protein interactions are frequently remodeled, yet few studies capture their dynamic nature. In our recent study, we profiled the dynamics of the E. coli interactome under different environments, advancing accurate modeling of dynamic biological systems.
Multi-Omics Profiling of Hypertrophic Cardiomyopathy Reveals Altered Mechanisms in Mitochondrial Dynamics and Excitation–Contraction Coupling
Hypertrophic cardiomyopathy is one of the most common inherited cardiomyopathies and a leading cause of sudden cardiac death in young adults. Despite profound insights into the genetics, there is imperfect correlation between mutation and clinical prognosis, suggesting complex molecular cascades driving pathogenesis. This study fills in gaps from previous studies by expanding knowledge of the initial responses to mutations that protect cells against the early stress prior to contractile dysfunction and overt disease.
